James' next novel was The Judas Strain, which came out in July 2007. The members of SIGMA Force seek to prevent an outbreak that could threaten the entire planet. It is based on the Hindu temple complex of Angkor Wat. The novel has been compared to those by Dan Brown. The book also marks the apparent death of Dr. Monk Kokalis and the introduction of new charchter Kowalski who acts as Gray Pierce's sidekick in this and later books. Among the things that happen are Gray's parents are captured and held hostage by one of the book's villains, sadistic Guild operative Annishen and are used as leverage by the Butcher of Calcutta, Amen Nasser to force Gray to cooperate. Thanks to his parents initiative and brilliance, they get away long enough for SIGMA to find and rescue them and Annishen is killed by Gray's father. This allows Gray to kill Nasser thanks to a trick taken from the Godfather, allowing SIGMA to win, getting the needed cure and defeating the Guild's plans, preventing a worldwide pandemic and preventing the Guild from gaining many new bio-weapons as a result of the Judas Strain. It's also revealed that Guild operative and assasian Seichan, who is sometimes an ally of Sigma, is actually a double-agent and good guy, being a member of an unknown organization that somehow infiltrated the Guild.